St. Aloysius School, located on Cleveland’s East Side in the Glenville neighborhood, was founded in 1903 with the establishment of the parish which served a largely Irish American population. The first African American student to attend St. Aloysius School—John Balazs—was a member of the class of 1942.

About a mile and a half down the street from St. Aloysius where E. 123rd Street, Superior Avenue, and Lakeview Roads intersect stands the Martin DePorres Center which was formerly St. Agatha School, an outgrowth of St. Thomas and St. Aloysius Schools in the 1940s. After a long study and resource-consolidation effort, St. Agatha and St. Aloysius Schools merged beginning in the 1973-1974 school year.

At the time, the Akron Dominican Sisters staffed St. Agatha School and the Sisters of St. Joseph from Rocky River staffed St. Aloysius School. Due to the scarcity of religious teachers in the early 1970s, more lay teachers were hired. Only one Sister of St. Joseph, TOSF remained at the merged schools. However, in 1981, Sister Sandra Sabo, SSJ, who had been a first and second grade teacher at St. Agatha-St. Aloysius School for eleven years, assumed the role of principal. In 1981, Ursuline Sister Mary Jean Raymond joined the St. Agatha-St. Aloysius School staff and assumed the roles of first grade teacher and coordinator for primary grade liturgies and religious activities.

St. Agatha-St. Aloysius School is located in what is called "the Glenville area,” and has a student-family poverty level of 87%. Our current school population is 100% African-American Heritage in grades kindergarten through eight. In order to minister and teach effectively to the students today, there have been on-going efforts and programs initiated by the parish and the staff to correlate and integrate the Catholic-Christian identity of St. Agatha-St. Aloysius School with the cultural identity and needs of the students and their families.